Over consumption of added sugars by the American public continues to be problematic. For health reasons as well as achieving weight management. According to the 2020-2025 Dietary Guidelines Committee Advisory Report, we should aim to consume less than 6% of our calories as added sugars. The use of low- and no-calorie sweeteners can assist consumers to reduce this consumption. In this article we review the evidence that supports the safety and efficacy of low- and no-calorie sweeteners and offer clinicians practical strategies with which to assess consumption of added sugars. We also offer clinicians a step-by-step approach to help consumers reduce their added sugars intake with one being use low- and no-calorie sweeteners to replace added sugars. The article offers insights about the importance of taste in a person’s food choices and how taste must be factored in when counseling. The citation for this article is: Clinical Diabetes. 2021;39(1):45-56. It is open access. Read here ...